Affiliation:
1. Department of Analytical Chemistry and Food Science Instituto de Agroecoloxía e Alimentación (IAA) – CITEXVI Universidade de Vigo Nutrition and Bromatology Group Vigo Spain
2. Division of Food Production and Society Biomarine Resource Valorisation Norwegian Institute of Bioeconomy Research Bodø Norway
3. Department of Pharmacology, Bromatology and Toxicology Faculty of Pharmacy and Biochemistry Universidad Nacional Mayor de San Marcos Lima Perú
4. Departamento de Ciencia de los Alimentos y Tecnología Química Facultad de Ciencias Químicas y Farmacéuticas Universidad de Chile Santiago Chile
Abstract
AbstractOchnaflavone is a naturally occurring biflavonoid mainly isolated from Ochna integerrima, manifests health benefits encompassing antidiabetic, anticancer, anti‐cardiovascular, and anti‐inflammatory activities. However, most bioactivity research has focused on in vitro experiments, rather than in vivo disease models, toxicological assessments, and human clinical trials. Moreover, a comprehensive review of the pharmacological aspects of ochnaflavone is conspicuously lacking. Thus, this review provides a concise and comprehensive summary of existing knowledge on the chemical structure, plant origin, physical properties, biotransformations, and multifaceted biological activities of ochnaflavone along with an in‐depth exploration of the complex molecular mechanisms behind these activities, including signaling pathways and gene expression regulation, with the aim of promoting future theoretical needs for ochnaflavone in clinical trials and providing comprehensive insights into the research and application of this valuable natural compound.