Population Pharmacokinetics of Lopinavir/Ritonavir: Changes Across Formulations and Human Development From Infancy Through Adulthood

Author:

Yang Jincheng1,Nikanjam Mina2,Best Brookie M.13,Pinto Jorge4,Chadwick Ellen G.5,Daar Eric S.6,Havens Peter L.7,Rakhmanina Natella89,Capparelli Edmund V.13

Affiliation:

1. Skaggs School of Pharmacy and Pharmaceutical Science; University of California; San Diego CA USA

2. Division of Hematology-Oncology; University of California; San Diego CA USA

3. Division of Host-Microbe Systems and Therapeutics; University of California San Diego School of Medicine; San Diego CA USA

4. Division of Immunology; School of Medicine; Federal University of Minas Gerais; Minas Gerais Brazil

5. Northwestern University Feinberg School of Medicine; Chicago Illinois USA

6. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center; Los Angeles CA USA

7. Division of Pediatric Infectious Diseases; Medical College of Wisconsin and Children's Hospital of Wisconsin; Milwaukee WI USA

8. Division of Pediatric Infectious Diseases; Children's National Medical Center; The George Washington University; Washington DC USA

9. Elizabeth Glaser Pediatric AIDS Foundation; Washington DC USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference31 articles.

1. Guidelines for the use of antiretroviral agents in pediatric HIV infection https://aidsinfo.nih.gov/contentfiles/lvguidelines/PedARV_TablesOnly.pdf 2018

2. Sequential population pharmacokinetic modeling of lopinavir and ritonavir in healthy volunteers and assessment of different dosing strategies;Dickinson;Antimicrob Agents Chemother,2011

3. Simultaneous population pharmacokinetic model for lopinavir and ritonavir in HIV-infected adults;Molto;Clin Pharmacokinet,2008

4. Population pharmacokinetics of lopinavir in combination with ritonavir in HIV-1-infected patients;Crommentuyn;Br J Clin Pharmacol,2005

5. Population analysis of weight-, age-, and sex-related differences in the pharmacokinetics of lopinavir in children from birth to 18 years;Jullien;Antimicrob Agents Chemother,2006

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