Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

Author:

Khanova Elena1,Wu Raymond1,Wang Wen1,Yan Rui1,Chen Yibu2,French Samuel W.3,Llorente Cristina4,Pan Stephanie Q.1,Yang Qihong1,Li Yuchang1,Lazaro Raul1,Ansong Charles5,Smith Richard D.5,Bataller Ramon6ORCID,Morgan Timothy7,Schnabl Bernd4,Tsukamoto Hidekazu18

Affiliation:

1. Southern California Research Center for ALPD and Cirrhosis and Department of Pathology; Keck School of Medicine of the University of Southern California; Los Angeles CA

2. Bioinformatics Service; Keck School of Medicine of the University of Southern California; Los Angeles CA

3. Harbor-UCLA Medical Center; Torrance CA

4. Department of Medicine; University of California San Diego and VA San Diego Healthcare System; San Diego CA

5. Pacific Northwest National Laboratory; Richland WA

6. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine; University of Pittsburgh; Pittsburgh PA

7. Gastroenterology Services; VA Long Beach Healthcare System; Long Beach CA

8. Department of Veterans Affairs Greater Los Angeles Healthcare System; Los Angeles CA

Funder

National Institute on Alcohol Abuse and Alcoholism

National Institute of General Medical Sciences

Medical Research Service of Department of Veterans Affairs

Animal Core, Morphology Core, and Administrative Core of the Southern California Research Center for ALPD and Cirrhosis

Molecular Genomics Core and Bioinformatics Core of the USC Norris Comprehensive Cancer Center

Integrative Liver Cell Core

Clinical Resources for Alcoholic Hepatitis Investigators

USC

U.S. Department of Veterans Affairs

Publisher

Wiley

Subject

Hepatology

Reference42 articles.

1. Alcoholic hepatitis;Lucey;N Engl J Med,2009

2. A histologic scoring system for prognosis of patients with alcoholic hepatitis;Altamirano;Gastroenterology,2014

3. Prednisolone or Pentoxifylline for Alcoholic Hepatitis;Thursz;N Engl J Med,2015

4. Early liver transplantation for severe alcoholic hepatitis;Mathurin;N Engl J Med,2011

5. Three-year Results of a Pilot Program in Early Liver Transplantation for Severe Alcoholic Hepatitis;Lee;Ann Surg,2017

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