Dimorphic Mechanisms of Fragility in Diabetes Mellitus: the Role of Reduced Collagen Fibril Deformation

Author:

Wölfel Eva M.12,Schmidt Felix N.1,vom Scheidt Annika13ORCID,Siebels Anna K.1,Wulff Birgit4,Mushumba Herbert4,Ondruschka Benjamin4,Püschel Klaus4,Scheijen Jean5,Schalkwijk Casper G.5,Vettorazzi Eik6,Jähn‐Rickert Katharina17ORCID,Gludovatz Bernd8,Schaible Eric9,Amling Michael1ORCID,Rauner Martina101112ORCID,Hofbauer Lorenz C.101112ORCID,Zimmermann Elizabeth A.13,Busse Björn12ORCID

Affiliation:

1. Department of Osteology and Biomechanics University Medical Center Hamburg‐Eppendorf Hamburg Germany

2. Interdisciplinary Competence Center for Interface Research (ICCIR) University Medical Center Hamburg‐Eppendorf Hamburg Germany

3. Department of Macroscopic and Clinical Anatomy, Gottfried Schatz Research Center Medical University of Graz Graz Austria

4. Institute of Legal Medicine University Medical Center Hamburg‐Eppendorf Hamburg Germany

5. Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM) School for Cardiovascular Diseases Maastricht University Maastricht The Netherlands

6. Institute of Medical Biometry and Epidemiology University Medical Center Hamburg‐Eppendorf Hamburg Germany

7. Mildred Scheel Cancer Career Center Hamburg University Cancer Center Hamburg, University Medical Center Hamburg‐Eppendorf Hamburg Germany

8. School of Mechanical and Manufacturing Engineering University of New South Wales (UNSW Sydney) Sydney New South Wales Australia

9. Advanced Light Source Lawrence Berkeley National Laboratory Berkeley CA USA

10. Department of Medicine III Technische Universität Dresden Medical Center Dresden Germany

11. Center for Healthy Aging Technische Universität Dresden Medical Center Dresden Germany

12. Center for Regenerative Therapies Dresden Technische Universität Dresden Dresden Germany

13. Faculty of Dental Medicine and Oral Health Sciences McGill University Montreal Quebec Canada

Funder

Universitätsklinikum Hamburg-Eppendorf

European Commission

Horizon 2020 Framework Programme

Deutsche Forschungsgemeinschaft

Alexander von Humboldt Foundation

Lawrence Berkeley National Laboratory

Office of Science

U.S. Department of Energy

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

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