Myocardial blood flow determination from contrast‐free magnetic resonance imaging quantification of coronary sinus flow

Author:

Tingsgaard Jakob Koefoed1ORCID,Sørensen Martin Heyn2,Bojer Annemie Stege2,Anderson Robert H.3,Broadbent David Andrew45ORCID,Plein Sven5,Gæde Peter2,Madsen Per Lav16

Affiliation:

1. Department of Cardiology Copenhagen University Hospital Copenhagen Denmark

2. Department of Internal Medicine Slagelse‐Næstved Hospital Denmark

3. Institute of Genetic Medicine Newcastle University UK

4. Department of Medical Physics and Engineering Leeds Teaching Hospitals Leeds UK

5. Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds Leeds UK

6. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

Abstract

BackgroundDetermination of myocardial blood flow (MBF) with MRI is usually performed with dynamic contrast enhanced imaging (MBFDCE). MBF can also be determined from coronary sinus blood flow (MBFCS), which has the advantage of being a noncontrast technique. However, comparative studies of MBFDCE and MBFCS in large cohorts are lacking.PurposeTo compare MBFCS and MBFDCE in a large cohort.Study TypeProspective, sequence‐comparison study.Population147 patients with type 2 diabetes mellitus (age: 56+/−12 years; 106 male; diabetes duration: 12.9+/−8.1 years), and 25 age‐matched controls.Field Strength/Sequences1.5 Tesla scanner. Saturation recovery sequence for MBFDCE vs. phase‐contrast gradient‐echo pulse sequence (free‐breathing) for MBFCS.AssessmentMBFDCE and MBFCS were determined at rest and during coronary dilatation achieved by administration of adenosine at 140 μg/kg/min. Myocardial perfusion reserve (MPR) was calculated as the stress/rest ratio of MBF values. Coronary sinus flow was determined twice in the same imaging session for repeatability assessment.Statistical TestsAgreement between MBFDCE and MBFCS was assessed with Bland and Altman's technique. Repeatability was determined from single‐rater random intraclass and repeatability coefficients.ResultsRest and stress flows, including both MBFDCE and MBFCS values, ranged from 33 to 146 mL/min/100 g and 92 to 501 mL/min/100 g, respectively. Intraclass and repeatability coefficients for MBFCS were 0.95 (CI 0.90; 0.95) and 5 mL/min/100 g. In Bland–Altman analysis, mean bias at rest was –1.1 mL/min/100 g (CI −3.1; 0.9) with limits of agreement of −27 and 24.8 mL/min/100 g. Mean bias at stress was 6.3 mL/min/100 g (CI −1.1; 14.1) with limits of agreement of −86.9 and 99.9. Mean bias of MPR was 0.11 (CI: −0.02; 0.23) with limits of agreement of −1.43 and 1.64.ConclusionMBF may be determined from coronary sinus blood flow, with acceptable bias, but relatively large limits of agreement, against the reference of MBFDCE.Level of Evidence1Technical Efficacy Stage2

Publisher

Wiley

Subject

Radiology, Nuclear Medicine and imaging

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3