Ineffective quinidine therapy in early onset epileptic encephalopathy withKCNT1mutation
Author:
Affiliation:
1. Department of Pediatric Neurology; Fukuoka Children's Hospital; Fukuoka
2. Department of Human Genetics; Graduate School of Medicine, Yokohama City University; Yokohama Japan
Publisher
Wiley
Subject
Neurology (clinical),Neurology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/ana.24598/fullpdf
Reference5 articles.
1. Targeted treatment of migrating partial seizures of infancy with quinidine;Bearden;Ann Neurol,2014
2. KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine;Milligan;Ann Neurol,2014
3. De novo KCNT1 mutations in early-onset epileptic encephalopathy;Ohba;Epilepsia,2015
4. Quinidine in the treatment of KCNT1 positive epilepsies;Mikati;Ann Neurol
5. Effects of seizures on developmental processes in the immature brain;Ben-Ari;Lancet Neurol,2006
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1. Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy;Scientific Reports;2024-02-09
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3. Potassium channelopathies associated with epilepsy-related syndromes and directions for therapeutic intervention;Biochemical Pharmacology;2023-02
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