Liquid chromatography mass spectrometry simultaneous determination of vindoline and catharanthine in rat plasma and its application to a pharmacokinetic study

Author:

Lin Chongliang1,Cai Jinzhang2,Yang Xuezhi1,Hu Lufeng1,Lin Guanyang1

Affiliation:

1. The First Affiliated Hospital of Wenzhou Medical University; Wenzhou 325000 China

2. The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University; Wenzhou 325000 China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference19 articles.

1. Simultaneous determination of vinblastine and its monomeric precursors vindoline and catharanthine in Catharanthus roseus by capillary electrophoresis-mass spectrometry;Chen;Journal of Separation Science,2011

2. European Medicines Agency Guideline on bioanalytical method validation 2011 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf

3. Simultaneous determination of vincristine, vinblastine, catharanthine, and vindoline in leaves of catharanthus roseus by high-performance liquid chromatography;Gupta;Journal of Chromatographic Science,2005

4. Calcium channel blockers and stroke;Inzitari;Aging Clinical and Experimenal Research,2005

5. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes;Jadhav;Journal of Pharmacology and Experimental Therapy,2013

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