Affiliation:
1. Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China
2. Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Shanghai 200240 P. R. China
Abstract
AbstractDNA combined with other functional nanomaterials plays crucial roles in biomedical areas, including bio‐detection, bioimaging, as well as disease diagnosis and treatment. Rapid advances in DNA composites for biological applications have been achieved during the past few decades. In this review, it is first summarized the synthesis methods of DNA composites with inorganic core and organic core, as well as the applications of DNA composites in cancer diagnosis. The in vitro detection of various disease biomarkers and in vivo tumor imaging using DNA composites are introduced. Finally, main challenges and the new frontiers in the field of using DNA composites for cancer diagnosis are summarized.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China