Affiliation:
1. Center of Single‐Molecule Sciences Institute of Modern Optics College of Electronic Information and Optical Engineering Nankai University 38 Tongyan Road, Jinnan District Tianjin 300350 P. R. China
2. Network for Computational Nanotechnology Purdue University West Lafayette IN 47907 USA
3. Beijing National Laboratory for Molecular Sciences National Biomedical Imaging Center College of Chemistry and Molecular Engineering Peking University 292 Chengfu Road, Haidian District Beijing 100871 P. R. China
Abstract
AbstractSingle‐biomolecule electronic sensing techniques are of great importance in many fields, from medical diagnosis to disease surveillance. As the physiological changes of single biomolecules can be converted into measurable electrical signals, single‐molecule electronic biosensors can realize real‐time, highly sensitive, and high‐bandwidth detection of individual intra‐ or inter‐molecular interactions. These powerful single‐molecule sensing devices have demonstrated key advantages in precisely providing rare and detailed intermediate information along reaction pathways and revealing unique properties hidden in ensemble measurements. This review summarizes significant advances in single‐molecule electronic biosensors, emphasizing biomolecule recognition, interaction, and reaction dynamics at the single‐molecule level. Sensor configurations, sensing mechanisms, and representative applications are also discussed. Furthermore, a perspective on the use of photoelectric integrated systems for synchronous sensing of the electrical and optical signals of single biomolecules is provided.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Natural Science Foundation of Beijing Municipality
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献