Low neutralization of SARS‐CoV‐2 Omicron BA.5.2.48, BF.7.14, XBB.1 subvariants by homologous or heterologous booster-Reference-Cited by-同舟云学术

Low neutralization of SARS‐CoV‐2 Omicron BA.5.2.48, BF.7.14, XBB.1 subvariants by homologous or heterologous booster

Published:2023-12 Issue:12 Volume:95 Page:
ISSN:0146-6615
Container-title:Journal of Medical Virology
language:en
Short-container-title:Journal of Medical Virology

Author:

Li Jianhua¹²,Mao Haiyan¹²,Song Wanchen²³,Chen Yin¹²,Feng Yan⁴,Li Jiaxuan⁵,Su Lingxuan¹²,Li Xiaoyan²,Shi Wen²,Wu Yutong⁵,Huang Chen¹²,Zhang Yanjun¹²,Chen Keda⁵

Affiliation:

1. Key Laboratory of Public Health Detection and Etiological Research of Zhejiang Province Hangzhou China

2. Department of Microbiology Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China

3. School of Medical Technology and Information Engineering Zhejiang Chinese Medical University Hangzhou China

4. Department of Infectious Diseases Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China

5. Shulan International Medical College Zhejiang Shuren University Hangzhou China

Abstract

AbstractThe recently mutated severe acute respiratory syndrome coronavirus 2 variant Omicron has very high infectivity and a strong ability to evolve and evade immunity. We collected six sets of sera from uninfected individuals and individuals recovering from breakthrough infections who completed homologous or heterologous booster immunization and assessed their susceptibility against the BA.5.2.48, BF.7.14, XBB.1.5, XBB.1.5.4, and XBB.1.16 subvariants. The results demonstrated that the Omicron variants possess an exceptional potential to evade the immune barriers strengthened by vaccine administration and natural infections in the population, particularly XBB.1.16, and showed that heterologous boosters exhibit higher vaccine efficacy compared with homologous boosters.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Infectious Diseases,Virology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.29306

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