Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

Author:

Kesari Pooja1ORCID,Deshmukh Anuradha1ORCID,Pahelkar Nikhil1ORCID,Suryawanshi Abhishek B.1ORCID,Rathore Ishan1ORCID,Mishra Vandana1,Dupuis John H.2,Xiao Huogen3,Gustchina Alla4,Abendroth Jan56,Labaied Mehdi56,Yada Rickey Y.2,Wlodawer Alexander4ORCID,Edwards Thomas E.56,Lorimer Donald D.56,Bhaumik Prasenjit1ORCID

Affiliation:

1. Department of Biosciences and Bioengineering Indian Institute of Technology Bombay Mumbai India

2. Food, Nutrition, and Health Program, Faculty of Land and Food Systems University of British Columbia Vancouver British Columbia Canada

3. Summerland Research and Development Center Agriculture and Agri‐Food Canada Summerland British Columbia Canada

4. Protein Structure Section, Center for Structural Biology National Cancer Institute Frederick Maryland USA

5. UCB Pharma Bainbridge Island Washington USA

6. Seattle Structural Genomics Center for Infectious Disease Seattle Washington USA

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Michigan Economic Development Corporation

National Cancer Institute

Purdue University Center for Cancer Research

National Institute of Allergy and Infectious Diseases

Natural Sciences and Engineering Research Council of Canada

National Institutes of Health

Indian Institute of Technology Bombay

Industrial Research and Consultancy Centre

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

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