Structures of plasmepsin X from <i>Plasmodium falciparum</i> reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme-Reference-Cited by-同舟云学术

Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

Published:2022-02-05 Issue:4 Volume:31 Page:882-899
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Kesari Pooja¹^ORCID,Deshmukh Anuradha¹^ORCID,Pahelkar Nikhil¹^ORCID,Suryawanshi Abhishek B.¹^ORCID,Rathore Ishan¹^ORCID,Mishra Vandana¹,Dupuis John H.²,Xiao Huogen³,Gustchina Alla⁴,Abendroth Jan⁵⁶,Labaied Mehdi⁵⁶,Yada Rickey Y.²,Wlodawer Alexander⁴^ORCID,Edwards Thomas E.⁵⁶,Lorimer Donald D.⁵⁶,Bhaumik Prasenjit¹^ORCID

Affiliation:

1. Department of Biosciences and Bioengineering Indian Institute of Technology Bombay Mumbai India

2. Food, Nutrition, and Health Program, Faculty of Land and Food Systems University of British Columbia Vancouver British Columbia Canada

3. Summerland Research and Development Center Agriculture and Agri‐Food Canada Summerland British Columbia Canada

4. Protein Structure Section, Center for Structural Biology National Cancer Institute Frederick Maryland USA

5. UCB Pharma Bainbridge Island Washington USA

6. Seattle Structural Genomics Center for Infectious Disease Seattle Washington USA

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Michigan Economic Development Corporation

National Cancer Institute

Purdue University Center for Cancer Research