Measurable residual disease, conditioning regimen intensity, and age predict outcome of allogeneic hematopoietic cell transplantation for acute myeloid leukemia in first remission: A registry analysis of 2292 patients by the Acute Leukemia Working Party E

Author:

Gilleece Maria H.1ORCID,Labopin Myriam2,Yakoub-Agha Ibrahim3,Volin Liisa4,Socié Gerard5,Ljungman Per6,Huynh Anne7,Deconinck Eric8,Wu Depei9,Bourhis Jean Henri10,Cahn Jean Yves11,Polge Emmanuelle12,Mohty Mohamad13,Savani Bipin N.14,Nagler Arnon15

Affiliation:

1. Department of Haematology; Leeds Teaching Hospitals Trust, University of Leeds; Leeds United Kingdom

2. EBMT Paris Study Office/CEREST-TC; Paris France

3. CHU de Lille, LIRIC, INSERM U995; Université de Lille; Lille France

4. Comprehensive Cancer Center, Stem Cell Transplantation Unit; Helsinki University Hospital; Helsinki Finland

5. Service d'Hématologie Greffe; Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris; Paris France

6. Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital; Stockholm Sweden

7. Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole; Toulouse France

8. Hematology Department; CHRU Besancon, INSERM UMR1098, Universite de Franche-Comte; Besancon France

9. Department of Hematology; First Affiliated Hospital of Soochow University; Suzhou Jiangsu China

10. Department of Haematology; Institute Gustave Roussy; Paris France

11. Department of Haematology, Centre Hospital; Universitaire Grenoble Alpes; Grenoble France

12. Acute Leukemia Working Party; European Society for Blood and Marrow Transplantation Paris Study Office/European Center for Biostatistical and Epidemiological Evaluation in Hematopoietic Cell Therapy (CEREST-TC); Paris France

13. Hopital Saint-Antoine, Université Pierre and Marie Curie, Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche U938; Paris France

14. Division of Hematology/Oncology, Department of Internal Medicine; Vanderbilt University Medical Center; Nashville Tennessee

15. Chaim Sheba Medical Center; Tel Aviv University; Tel-Hashomer Israel

Funder

The study was supported by the European Blood & Marrow Transplantation funded by annual subscription from the constituent transplant centers.

European Blood & Marrow Transplantation

Publisher

Wiley

Subject

Hematology

Reference97 articles.

1. Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?;Cornelissen;Blood,2007

2. Reduced mortality after allogeneic hematopoietic-cell transplantation;Gooley;N Engl J Med,2010

3. The European LeukemiaNet AML working party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach;Cornelissen;Nat Rev Clin Oncol,2012

4. High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study;Terwijn;J Clin Oncol Off J Am Soc Clin Oncol,2013

5. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel;Döhner;Blood,2016

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