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Tailoring recombinant protein quality by rational media design

Published:2015-04-29 Issue:3 Volume:31 Page:615-629
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Brühlmann David¹²,Jordan Martin¹,Hemberger Jürgen³,Sauer Markus²,Stettler Matthieu¹,Broly Hervé¹

Affiliation:

1. Merck Serono SA, Corsier-sur-Vevey, Biotech Process Sciences, Zone Industrielle B; CH-1809 Fenil-sur-Corsier Switzerland

2. Dept. of Biotechnology and Biophysics; Julius-Maximilians-Universität Würzburg, Biozentrum; Am Hubland DE-97074 Würzburg Germany

3. Inst. for Biochemical Engineering and Analytics; University of Applied Sciences Giessen; Wiesenstrasse 14, DE-35390 Giessen Germany

Publisher

Wiley

Subject

Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/btpr.2089/fullpdf

Reference163 articles.

1. Mammalian cell protein expression for biopharmaceutical production;Zhu;Biotechnol Adv,2012

2. Towards dynamic metabolic flux analysis in CHO cell cultures;Ahn;Biotechnol J,2012

3. Production of recombinant protein therapeutics in cultivated mammalian cells;Wurm;Nat Biotechnol,2004

4. Cell culture processes for monoclonal antibody production;Li;mAbs,2010

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