No evidence for interactions of dimethylfumarate (DMF) and its main metabolite monomethylfumarate (MMF) with human cytochrome P450 (CYP) enzymes and the P‐glycoprotein (P‐gp) drug transporter-Reference-Cited by-同舟云学术

No evidence for interactions of dimethylfumarate (DMF) and its main metabolite monomethylfumarate (MMF) with human cytochrome P450 (CYP) enzymes and the P‐glycoprotein (P‐gp) drug transporter

Published:2019-12 Issue:6 Volume:7 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Aubets Jordi¹^ORCID,Jansat Josep‐Maria¹,Salva Miquel¹,Birks Vicky M.²,Cole Richard J.²,Lewis Jenny²,Pitcher Annabell²,Hall Michael²

Affiliation:

1. Department of DMPK Development Almirall S.A. Barcelona Spain

2. Pharmaron UK Ltd. Rushden UK

Funder

Almirall S.A.

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.540

Reference23 articles.

1. A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis

2. European Medicines Agency (EMA).2019.Skilarence SmPC.https://www.medicines.org.uk/emc/product/752/smpc. Accessed September 19 2019.

3. Efficacy and safety of LAS41008 (dimethyl fumarate) in adults with moderate-to-severe chronic plaque psoriasis: a randomized, double-blind, Fumaderm®- and placebo-controlled trial (BRIDGE)

4. European Medicines Agency (EMA).Tecfidera 120mg gastro‐resistant hard capsules SmPC.2019.https://www.medicines.org.uk/emc/product/5256/smpc. Accessed September 19 2019.

5. Detection of Metabolites of Fumaric Acid Esters in Human Urine: Implications for Their Mode of Action

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