Dialysis with bipolar affective disorder: experience of competing treatments

Author:

Abbey Emma1,Jenkins James2

Affiliation:

1. Dr Abbey is a Consultant in Old Age Psychiatry, Charlton Lane Hospital, Cheltenham, Gloucestershire, UK

2. Mr Jenkins is a patient expert by experience.

Abstract

The interaction of several serious illnesses presents considerable difficulty for both clinicians and patients, no matter what the coexisting diseases are. This results in huge anxiety for patients and worsens the difficulties understanding the risks and benefits of the treatment of each disorder. The authors present the clinical scenario where dialysis was commenced while sodium valproate was being taken for bipolar affective disorder, demonstrating the interface between bipolar affective disorder and renal failure and how their treatments caused deterioration in the comorbid condition. This case challenges accepted wisdom regarding the effects of dialysis on the sodium valproate levels in the body and discusses key clinical management issues.

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical),Neurology,Pshychiatric Mental Health

Reference10 articles.

1. National Institute for Health and Care Excellence: Valproate prescribing information2022 https://cks.nice.org.uk/topics/bipolar-disorder/prescribing-information/valproate. accessed 13 July 2023

2. Managing Antiepileptic Medication in Dialysis Patients;Rodriguez KAM;Curr Treat Options Neurol,2018

3. Hemodiafiltration and High-Flux Hemodialysis Significantly Reduce Serum Valproate Levels Inducing Epileptic Seizures: Case Report

4. Pharmacological monitoring of antiepileptic drugs in epilepsy patients on haemodialysis

5. Use of psychotropics in patients with kidney failure;Levy MB;Psychosomatics,1985

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