Spatial mapping of corneal biomechanical properties using wave‐based optical coherence elastography

Author:

Wang Qingying1,Chen Yulei2,Shen Kexin1,Zhou Xingyu1,Shen Meixiao3,Lu Fan45,Zhu Dexi3

Affiliation:

1. Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou Zhejiang China

2. Department of Ophthalmology Dongguan Tungwah Hospital Dongguan China

3. National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University Wenzhou China

4. State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University Wenzhou China

5. National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University Wenzhou China

Abstract

AbstractQuantifying the mechanical properties of the cornea can provide valuable insights into the occurrence and progression of keratoconus, as well as the effectiveness of corneal crosslinking surgery. This study presents a non‐contact and non‐invasive wave‐based optical coherence elastography system that utilizes air‐pulse stimulation to create a two‐dimensional map of corneal elasticity. Homogeneous and dual concentration phantoms were measured with the sampling of 25 × 25 points over a 6.6 × 6.6 mm2 area, to verify the measurement capability for elastic mapping and the spatial resolution (0.91 mm). The velocity of elastic waves distribution of porcine corneas before and after corneal crosslinking surgery were further mapped, showing a significant change in biomechanics in crosslinked region. This system features non‐invasiveness and high resolution, holding great potential for application in ophthalmic clinics.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Wiley

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