Optical coherence elastography with osmotically induced strains: Preliminary demonstration for express detection of cartilage degradation

Author:

Alexandrovskaya Yulia M.1,Kasianenko Ekaterina M.23,Sovetsky Alexander A.2,Matveyev Alexander L.2,Atyakshin Dmitry A.4,Patsap Olga I.4,Ignatiuk Mikhail A.4,Volodkin Artem V.4,Zaitsev Vladimir Y.2

Affiliation:

1. Terra Quantum GmbH Munich Germany

2. A.V. Gaponov‐Grekhov Institute of Applied Physics of the Russian Academy of Sciences Nizhny Novgorod Russia

3. National Research Center Kurchatov Institute Moscow Russia

4. Scientific and Educational Resource Center “Molecular Morphology”, RUDN University Moscow Russia

Abstract

AbstractOptical coherence elastography (OCE) demonstrated impressive abilities for diagnosing tissue types/states using differences in their biomechanics. Usually, OCE visualizes tissue deformation induced by some additional stimulus (e.g., contact compression or auxiliary elastic‐wave excitation). We propose a new variant of OCE with osmotically induced straining (OIS‐OCE) and demonstrate its application to assess various stages of proteoglycan content degradation in cartilage. The information‐bearing signatures in OIS‐OCE are the magnitude and rate of strains caused by the application of osmotically active solutions onto the sample surface. OCE examination of the induced strains does not require special tissue preparation, the osmotic stimulation is highly reproducible, and strains are observed in noncontact mode. Several minutes suffice to obtain a conclusion. These features are promising for intraoperative method usage when express assessment of tissue state is required during surgical operations. The “waterfall” images demonstrate the development of cumulative osmotic strains in control and degraded cartilage samples.

Funder

Russian Science Foundation

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3