Implementation of a portable diffraction phase microscope for digital histopathology

Author:

Aimakov Nurbolat1,Min Eunjung2,Ban Sungbea1,Lee Sangjin1,Bae Jung Kweon1,You Joon S.13,Jung Woonggyu1ORCID

Affiliation:

1. Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan Republic of Korea

2. Korea Photonics Technology Institute Gwangju Republic of Korea

3. Incipian LLC Laguna Niguel California USA

Abstract

AbstractQuantitative phase imaging (QPI) has a significant advantage in histopathology as it helps in differentiating biological tissue structures and cells without the need for staining. To make this capability more accessible, it is crucial to develop compact and portable systems. In this study, we introduce a portable diffraction phase microscopy (DPM) system that allows the acquisition of phase map images from various organs in mice using a low‐NA objective lens. Our findings indicate that the cell and tissue structures observed in portable DPM images are similar to those seen in conventional histology microscope images. We confirmed that the developed system's performance is comparable to the benchtop DPM system. Additionally, we investigate the potential utility of digital histopathology by applying deep learning technology to create virtual staining of DPM images.

Funder

Korea Medical Device Development Fund

National Research Foundation of Korea

Publisher

Wiley

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