Adjuvant effect of antimicrobial photodynamic therapy (aPDT) in the treatment of diabetic foot ulcers: A case series

Author:

Ferreira Rita de Cassia12,Cecatto Rebeca Boltes1ORCID,Perez Silvana Torres12,Mesquita‐Ferrari Raquel Agnelli13ORCID,Bussadori Sandra Kalil13ORCID,Duran Cinthya Cosme1ORCID,Horliana Anna Carolina Tempestini1ORCID,Fernandes Kristianne Porta Santos1ORCID

Affiliation:

1. Postgraduate Program in Biophotonics Medicine Universidade Nove de Julho (UNINOVE) São Paulo São Paulo Brazil

2. Conjunto Hospitalar do Mandaqui São Paulo São Paulo Brazil

3. Postgraduate Program in Rehabilitation Sciences Universidade Nove de Julho (UNINOVE) São Paulo São Paulo Brazil

Abstract

AbstractThis study aimed to evaluate the clinical evolution of patients with diabetic foot ulcer treated with antimicrobial photodynamic therapy (aPDT) using the Bates‐Jensen (BJ) scale. A total of 21 patients were monitored, with an average age of 58 years. Patients underwent the standard treatment protocol of the institution, supplemented with aPDT utilizing 0.01% methylene blue (MB) and laser irradiation (660 nm, 100 mW, 6 J per point). Following aPDT, the lesions were protected with hydrofiber dressings containing silver. The Bates‐Jensen Scale was employed at pre‐treatment and post‐aPDT sessions to assess lesion progression. The results demonstrated a significant difference between pre‐ and post‐treatment values in the overall BJ score. The use of MB in aPDT proved to be an effective, safe, well‐tolerated treatment with high patient adherence and the potential for implementation in the care of diabetic foot conditions.

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Materials Science,General Chemistry

Reference34 articles.

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