Photobiomodulation increases uprighting tooth movement and modulates IL‐1β expression during orthodontically bone remodeling
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Published:2023-06-21
Issue:9
Volume:16
Page:
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ISSN:1864-063X
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Container-title:Journal of Biophotonics
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language:en
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Short-container-title:Journal of Biophotonics
Author:
Murakami‐Malaquias‐Silva Felipe1,
Perim Rosa Ellen1,
Malavazzi Tainá Caroline Santos1ORCID,
Silva Tamiris1,
de Santana Sarmento Dmitry José2ORCID,
Garcez Aguinaldo Silva3ORCID,
Fernandes Marcella Ueda R.3,
Tortamano Andre4,
Ramalho Karen Muller5ORCID,
Motta Lara Jansiski1ORCID,
Fernandes Kristianne Porta Santos1ORCID,
Bussadori Sandra Kalil1ORCID,
Mesquita‐Ferrari Raquel Agnelli1ORCID,
Horliana Anna Carolina Ratto Tempestini1ORCID
Affiliation:
1. Postgraduate Program in Biophotonics Applied to Health Sciences Universidade Nove de Julho (UNINOVE) São Paulo Brazil
2. Universidade Estadual da Paraíba João Pessoa Brazil
3. São Leopoldo Mandic School of Dentistry São Paulo Brazil
4. Department of Orthodontics, School of Dentistry University of São Paulo São Paulo Brazil
5. School of Dentistry Israelita Albert Einstein Fondation São Paulo Brazil
Abstract
AbstractThis study investigated the effects of photobiomodulation (PBM) in acceleration of orthodontic movement of inferior molar uprighting movement. Thirty‐four individuals, with indication of molar uprighting movement for oral rehabilitation, were randomly divided in two groups: verticalization + PBM (808 nm, 100 mW, 1 J per point, 10 points and 25 J/cm2) or verticalization + PBM simulation. Elastomeric chain ligatures were changed every 30 days for 3 months. FBM was performed immediately, 24 h, 72 h, 1 and 2 months after activation. The primary outcome was the amount of uprighting movement. Secondary outcomes were pain, amount of medication, OHIP‐14 questionnaire, and cytokine IL‐1β. PBM group increase uprighting movement when compared to control after 3 months and modulate IL‐1β expression. For pain control, the amount of medication and OHIP‐14 no difference were found. This study suggests that PBM accelerates tooth movement during molar uprighting, due to modulation of IL‐1β during bone remodeling.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação de Amparo à Pesquisa do Estado de São Paulo
Subject
General Physics and Astronomy,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Materials Science,General Chemistry