Affiliation:
1. Institute of Applied Physics, Russian Academy of Sciences Nizhny Novgorod Russia
2. Privolzhsky Research Medical University Nizhny Novgorod Russia
3. Nizhny Novgorod State University Nizhny Novgorod Russia
Abstract
AbstractOptical coherence tomography (OCT) is a promising tool for intraoperative tissue morphology determination. Several studies suggest that attenuation coefficient derived from the OCT images, can differentiate between tissues of different morphology, such as normal and pathological structures of the brain, skin, and other tissues. In the present study, the depth‐resolved method for attenuation coefficient calculation was adopted for the real‐world situation of the depth‐dependent OCT sensitivity and additive imaging noise with nonzero mean. It was shown that in the case of sharp focusing (~10 μm spot full width at half maximum [FWHM] or smaller at 1.3 μm central wavelength) only the proposed method for depth‐dependent sensitivity compensation does not introduce misleading artifacts into the calculated attenuation coefficient distribution. At the same time, the scanning beam focus spot with FWHM greater than 10 μm at 1.3 μm central wavelength allows one to use multiple approaches to the attenuation coefficient calculation without introducing noticeable bias. This feature may hinder the need for robust corrections for the depth‐resolved attenuation coefficient estimations from the community.
Funder
Russian Science Foundation
Subject
General Physics and Astronomy,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Materials Science,General Chemistry
Cited by
3 articles.
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