Effects of photobiomodulation at various irradiances on normal and dihydrotestosterone‐treated human hair dermal papilla cells in vitro

Author:

Sun Miao12,Jiang Hui23,Lin Shangfei23,Qin Haokuan23,Ding Xiaolei4,Lai Yongxian5,Liu Shangfeng6,Liu Muqing123ORCID

Affiliation:

1. Department of Light Source and Illuminating Engineering Fudan University Shanghai China

2. Zhongshan Fudan Joint Innovation Center Zhongshan Guangdong China

3. Institute of Future Lighting, Academy for Engineering and Technology Fudan University Shanghai China

4. Shanghai Engineering Research Center of Organ Repair, School of Medicine Shanghai University Shanghai China

5. Department of Dermatologic Surgery, Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai China

6. Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital Fudan University Shanghai China

Abstract

AbstractAndrogenetic alopecia (AGA) is the most common type of hair loss caused by dihydrotestosterone (DHT) binding to androgen receptors in dermal papilla cells (DPCs). Photobiomodulation (PBM) is a promising treatment for AGA but suffers from inconsistent outcomes and inconsistent effective light parameters. This study investigated the impact of red light at various irradiances on normal and DHT‐treated DPCs. Our results suggested that red light at 8 mW/cm2 was most effective in promoting DPCs growth. Furthermore, a range of irradiances from 2 to 64 mW/cm2 modulated key signaling pathways, including Wnt, FGF, and TGF, in normal and DHT‐treated DPCs. Interestingly, 8 mW/cm2 had a greater impact on these pathways in DHT‐treated DPCs and altered the Shh pathway, suggesting that the effect of PBM varies with the cellular environment. This study highlights specific factors that influence PBM effectiveness and provides insight into the need for personalized PBM treatment approaches.

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Materials Science,General Chemistry

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