Extracorporeal membrane oxygenation and effects on tendon tissue: A vibrational spectroscopy study

Author:

Stefani Sara1,Govoni Marco2,Tombolesi Niki1,Vivarelli Leonardo2,Dallari Dante2,Paolantoni Marco1,Sassi Paola1ORCID,Morresi Assunta1

Affiliation:

1. Department of Chemistry, Biology and Biotechnology University of Perugia Perugia Italy

2. Reconstructive Orthopaedic Surgery and Innovative Techniques—Musculoskeletal Tissue Bank IRCCS Istituto Ortopedico Rizzoli Bologna Italy

Abstract

AbstractExtracorporeal membrane oxygenation (ECMO) is an invasive medical technique used to provide life support in persons with insufficient cardiac and respiratory functionalities, or to preserve, postmortem, and organ function addressing organ/tissue transplant. Although a lot of information is available about organs in their entirety, the safety and effectiveness of allogeneic tissues collected from ECMO donors have not been fully elucidated. In this preliminary study, samples of tibial and peroneal human tendons were analyzed along their length with Raman microspectroscopy and attenuated total reflection‐Fourier transform infrared micro‐imaging. Both techniques evidenced a different chemical composition in the terminal with respect to the central part of the tendon. Thus, a differentiated analysis was performed depending on the specific position with respect to the bone or the muscle junctions. Spectroscopic analyses showed significant differences in the characteristics of the extracellular matrix between tendons from ECMO and non‐ECMO donors, suggesting changes in the amino acid (proline and hydroxyproline) content and protein structure.

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,General Biochemistry, Genetics and Molecular Biology,General Materials Science,General Chemistry

Reference20 articles.

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