Affiliation:
1. Clinical & Experimental Allergy Department of Dermatology and Allergology Philipps‐Universität Marburg University Hospital Marburg Marburg Germany
Abstract
AbstractThe significance of B‐cell memory in sustaining IgE‐mediated allergies but also ensuring the development of long‐term allergen tolerance has remained enigmatic. However, well‐thought murine and human studies have begun to shed more light on this highly disputed subject. The present mini review highlights important aspects, like the involvement of IgG1 memory B cells, the meaning of low‐ or high‐affinity IgE antibody production, the impact of allergen immunotherapy, or the relevance of local memory established by ectopic lymphoid structures. Based on recent findings, future investigations should lead to deeper knowledge and the development of improved therapies treating allergic individuals.
Funder
Deutsche Forschungsgemeinschaft
Subject
Immunology,Immunology and Allergy
Cited by
1 articles.
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