A simple and rapid HPLC-UV method for the determination of retigabine in human plasma

Author:

Franco Valentina1ORCID,Baruffi Katia1,Gatti Giuliana1,Marchiselli Roberto1,Fattore Cinzia2,Canevini Maria Paola34,Crema Francesca1,Perucca Emilio12

Affiliation:

1. Clinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics; University of Pavia; Pavia Italy

2. IRCCS Mondino Foundation; Pavia

3. Epilepsy Center; San Paolo Hospital; Milan Italy

4. Department of Health Sciences; Università degli Studi di Milano; Italy

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference12 articles.

1. Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases;Deeb;Journal of Analytical Toxicology,2014

2. European Medicines Agency 2011   Committee for Medicinal Products for Human Use: Guideline on Bioanalytical Method Validation http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf

3. Novel medications for epilepsy;Fattore;Drugs,2011

4. Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel;Faulkner;Expert Opinion on Drug Safety,2013

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