CRISPR/Cas9‐mediated knockout of HBsAg inhibits proliferation and tumorigenicity of HBV‐positive hepatocellular carcinoma cells

Author:

Song Jia123,Zhang Xiaochao123,Ge Qianyun123,Yuan Chaoyi123,Chu Liang123,Liang Hui‐fang123,Liao Zhibin123,Liu Qiumeng123,Zhang Zhanguo123,Zhang Bixiang123ORCID

Affiliation:

1. Hepatic Surgery Center, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

2. Hubei Province for the Clinical Medicine Research Center of Hepatic SurgeryWuhanChina

3. Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public HealthWuhanChina

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference48 articles.

1. Global cancer statistics, 2012;Torre LA;CA,2015

2. Epidemiology, natural history, and risk factors of hepatocellular carcinoma;Fares N;Rev Prat,2013

3. The global health burden of infection-associated cancers in the year 2002

4. Hepatocellular carcinoma epidemiology

5. Hepatitis B virus PreS/S gene variants: Pathobiology and clinical implications

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