Titanium‐Based Superlattice with Fe(III)‐Regulable Bandgap and Performance for Optimal and Synergistic Sonodynamic–Chemotherapy Guided by Magnetic Resonance Imaging

Author:

Liu Yanjun1,Qin Liying2,Tan Guoying1,Guo Yanan1,Fan Yifan1,Song Nan1,Zhou Ping2,Yan Chun‐Hua1,Tang Yu13ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 P. R. China

2. School/Hospital of Stomatology Lanzhou University Lanzhou 730000 P. R. China

3. State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare Earths Baotou 014030 P. R. China

Abstract

AbstractSuperlattices have considerable potential as sonosensitizers for cancer therapy because of their flexible and tunable band gaps, although they have not yet been reported. In this study, a Ti‐based organic–inorganic superlattice with good electron–hole separation was synthesized, which consisted of orderly layered superlattices of 2,2′‐bipyridine‐5,5′‐dicarboxylic acid (BPDC) and Ti−O layers. In addition, the superlattice was coordinated with Fe(III) and encapsulated doxorubicin (DOX) to prepare Ti‐BPDC@Fe@DOX@PEG (TFDP) after biocompatibility modification. TFDP can realize the simultaneous generation of reactive oxygen species and release of DOX under ultrasound irradiation. Moreover, adjusting the Fe(III) content can effectively modulate the band gap of the superlattice and increase the efficiency of sonodynamic therapy (SDT). The mechanisms underlying this modulation were explored. TFDP with Fe(III) can also be used as a contrast agent for magnetic resonance imaging (MRI). Both in vitro and in vivo experiments demonstrated the ability of TFDP to precisely treat cancer using MRI‐guided SDT/chemotherapy. This study expands the applications of superlattices as sonosensitizers with flexible and tailored modifications and indicates that superlattices are promising for precise and customized treatments.

Funder

National Natural Science Foundation of China

Science and Technology Program of Gansu Province

Higher Education Discipline Innovation Project

Publisher

Wiley

Subject

General Medicine

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