Electrocatalytic Synthesis of Pyridine Oximes using in Situ Generated NH2OH from NO species on Nanofiber Membranes Derived from NH2‐MIL‐53(Al)

Author:

Xiang Runan1,Wang Shihan1,Liao Peisen1,Xie Fangyan2,Kang Jiawei1,Li Suisheng1,Xian Jiahui1,Guo Linna2,Li Guangqin1ORCID

Affiliation:

1. Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University Guangzhou 510006 China

2. Instrumental Analysis & Research Center Sun Yat-Sen University No.135, Xingangxi Road Guangzhou 510275 China

Abstract

AbstractPyridine oximes produced from aldehyde or ketone with hydroxylamine (NH2OH) have been widely applied in pharmaceutics, enzymatic and sterilization. However, the important raw material NH2OH exhibits corrosive and unstable properties, leading to substantial energy consumption during storage and transportation. Herein, this work presents a novel method for directly synthesizing highly valuable pyridine oximes using in situ generated NH2OH from electrocatalytic NO reduction with well‐design nanofiber membranes (Al‐NFM) derived from NH2‐MIL‐53(Al). Particularly, 2‐pyridinealdoxime, the precursor of antidote pralidoxime (2‐PAM) for nerve agents suffering from scarcity and high cost, was achieved with a Faraday efficiency up to 49.8 % and a yield of 92.1 %, attributing to the high selectivity of NH2OH production on Al‐NFM, further easily reacted with iodomethane to produce 2‐PAM. This study proposes a creative approach, having wide universality for synthesizing pyridine and other oximes with a range of functional groups, which not only facilitates the conversion of exhaust gas (NO) and waste water (NO2) into valuable chemicals especially NH2OH production and in situ utilization through electrochemistry, but also holds significant potential for synthesis of neuro detoxifying drugs to humanity security.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Synthesis of Hydroxylamine via Ketone-Mediated Nitrate Electroreduction;Journal of the American Chemical Society;2024-04-06

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