Affiliation:
1. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
2. School of Applied Chemistry and Engineering University of Science and Technology of China Hefei 230026 China
3. Institute of Frontier and Interdisciplinarity Science and Institute of Molecular Sciences and Engineering Shandong University Qingdao 266237 China
Abstract
AbstractAlthough zeolitic imidazolate framework‐8 (ZIF‐8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF‐8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase‐1/gasdermin D (GSDMD)‐dependent pathway. The pyroptotic cell death is accompanied by necrosis and immunogenic cell death (ICD) simultaneously for efficient in situ immunity initiation. Meanwhile, carbonyl cyanide m‐chlorophenyl hydrazone (CCCP), a mitochondrial depolarizing agent, is successfully loaded into ZIF‐8 NPs and found to further enhance the pyroptosis process. Collectively, the obtained Pluronic F127‐modified CCCP‐incorporated ZIF‐8 NPs (F127ZIF‐8CCCPNPs) activate antitumor immunity and reprogram immunosuppressive tumor microenvironment (TME), realizing high‐efficiency tumor growth inhibition. This work will facilitate biomedicine applications of ZIF‐8 and provide good inspiration for pyroptosis‐induced cancer therapy.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Cited by
6 articles.
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