Affiliation:
1. Chair of Medicinal and Bioinorganic Chemistry School of Natural Sciences Department of Chemistry Technical University of Munich (TUM) Lichtenbergstr. 4 85748 Garching b. München Germany
2. Karlsruhe Institute of Technology (KIT) Institute of Nanotechnology Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen Germany
Abstract
AbstractThe discovery of the medicinal properties of gold complexes has fuelled the design and synthesis of new anticancer metallodrugs, which have received special attention due to their unique modes of action. Current research in the development of gold compounds with therapeutic properties is predominantly focused on the molecular design of drug leads with superior pharmacological activities, e.g., by introducing targeting features. Moreover, intensive research aims at improving the physicochemical properties of gold compounds, such as chemical stability and solubility in the physiological environment. In this regard, the encapsulation of gold compounds in nanocarriers or their chemical grafting onto targeted delivery vectors could lead to new nanomedicines that eventually reach clinical applications. Herein, we provide an overview of the state‐of‐the‐art progress of gold anticancer compounds, andmore importantly we thoroughly revise the development of nanoparticle‐based delivery systems for gold chemotherapeutics.
Funder
Alexander von Humboldt-Stiftung
Technische Universität München
Cited by
5 articles.
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