Spiky Artificial Peroxidases with V−O−Fe Pair Sites for Combating Antibiotic‐Resistant Pathogens

Author:

Huang Haoju1,Geng Wei2,Wu Xizheng1,Zhang Yiyun1,Xie Lan1,Ma Tian1,Cheng Chong13ORCID

Affiliation:

1. College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China

2. Department of Ultrasound West China Hospital Sichuan University Chengdu 610041 China

3. Med-X Center for Materials Sichuan University Chengdu 610065 China

Abstract

AbstractWith the sharp rise of antibiotic‐resistant pathogens worldwide, it is of enormous importance to create new strategies for combating pathogenic bacteria. Here, we create an iron oxide‐based spiky artificial peroxidase (POD) with V−O−Fe pair sites (V‐Fe2O3) for combating methicillin‐resistant Staphylococcus aureus (MRSA). The experimental studies and theoretical calculations demonstrate that the V‐Fe2O3 can achieve the localized “capture and killing” bifunction from the spiky morphology and massive reactive oxygen species (ROS) production. The V‐Fe2O3 can reach nearly 100 % bacterial inhibition over a long period by efficiently oxidizing the lipid membrane. Our wound disinfection results identify that the V‐Fe2O3 can not only efficiently eliminate MRSA and their biofilm but also accelerate wound recovery without causing noticeable inflammation and toxicity. This work offers essential insights into the critical roles of V−O−Fe pair sites and localized “capture and killing” in biocatalytic disinfection and provides a promising pathway for the de novo design of efficient artificial peroxidases.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Sichuan Province Science and Technology Support Program

Publisher

Wiley

Subject

General Medicine

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