Affiliation:
1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular Engineering East China Normal University 3663 N Zhongshan Road Shanghai 200062 China
2. Shanghai Frontiers Science Center of Molecule Intelligent Syntheses School of Chemistry and Molecular Engineering East China Normal University 3663 N Zhongshan Road Shanghai 200062 China
Abstract
AbstractHerein we reported a transition metal‐free deborylative cyclization strategy, based on which two routes have been developed, generating racemic and enantioenriched cyclopropylboronates. The cyclization of geminal‐bis(boronates) bearing a leaving group was highly diastereoselective, tolerating a few functional groups and applicable to heterocycles. When optically active epoxides were used as the starting materials, enantioenriched cyclopropylboronates could be efficiently prepared with >99 % stereospecificity. Mechanistic studies showed that the leaving group at the γ‐position played a crucial role and significantly promoted the activation of the gem‐diboron moiety.
Funder
East China Normal University
Thousand Young Talents Program of China