Stacking Cyclophanes into Chiral Microvessels

Abstract

AbstractEngineering novel micro‐/nanoscale systems and devices based on supramolecular assembly has tremendous potential from diverse applications perspective. However, controlling the size, shape, spatial arrangements, and hierarchical transcription by a dimensional organizing principle (1D–3D arrangement) without the help of templates remains a challenging task. In this vein, a recent study by Oki and colleagues reporting the stacking of chiral cyclophanes via intermolecular non‐covalent interactions for crafting synchronous microcrystalline 3D chiral vessels with controlled conformational arrangements represents a truly remarkable illustration of molecular engineering. The microvessels bear stereocontrolled skeletal morphology, recognize stereoisomers and serve as containers to accommodate microcrystals, polymer particles, and fluorescent dyes. The full application scope of this fascinating research is far beyond non‐covalent interactions, supramolecular self‐assembly, and crystal engineering.