Synthesis of Axially Chiral CF <sub>3</sub> ‐Substituted 2‐Arylpyrroles by Sequential Phosphine‐Catalyzed Asymmetric [3+2] Annulation and Oxidative Central‐to‐Axial Chirality Transfer-Reference-Cited by-同舟云学术

Synthesis of Axially Chiral CF ₃ ‐Substituted 2‐Arylpyrroles by Sequential Phosphine‐Catalyzed Asymmetric [3+2] Annulation and Oxidative Central‐to‐Axial Chirality Transfer

Published:2022-10-25 Issue:47 Volume:134 Page:
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angewandte Chemie

Author:

Xiang Alvin Tan Chuan¹²,Li Rui¹³,Zhang Fuhao¹,Dai Lei¹,Ullah Nisar⁴,Lu Yixin¹²³^ORCID

Affiliation:

1. Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 117543 Singapore

2. Integrative Sciences & Engineering Programme (ISEP) National University of Singapore 28 Medical Drive Singapore 117456 Singapore

3. Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City, Fuzhou Fujian 350207 China

4. Chemistry Department King Fahd University of Petroleum & Minerals Dhahran 31261 Saudi Arabia

Funder

National Research Foundation Singapore

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.202209494

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4. Recent encounters with atropisomerism in drug discovery

5. Atropisomerism in medicinal chemistry: challenges and opportunities