Die gerichtete Evolution einer Halogenid‐Methyltransferase erlaubt die biokatalytische Synthese diverser SAM‐Analoga-Reference-Cited by-同舟云学术

Die gerichtete Evolution einer Halogenid‐Methyltransferase erlaubt die biokatalytische Synthese diverser SAM‐Analoga

Published:2020-11-12 Issue:3 Volume:133 Page:1547-1551
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Tang Qingyun¹^ORCID,Grathwol Christoph W.²^ORCID,Aslan‐Üzel Aşkın S.¹^ORCID,Wu Shuke¹^ORCID,Link Andreas²^ORCID,Pavlidis Ioannis V.³^ORCID,Badenhorst Christoffel P. S.¹^ORCID,Bornscheuer Uwe T.¹^ORCID

Affiliation:

1. Institut für Biochemie Universität Greifswald Felix-Hausdorff-Straße 4 17489 Greifswald Deutschland

2. Institut für Pharmazie Universität Greifswald Friedrich-Ludwig-Jahn-Straße 17 17489 Greifswald Deutschland

3. Abteilung Chemie Universität Kreta, Voutes University Campus 70013 Heraklion Griechenland

Funder

China Scholarship Council

Horizon 2020 Framework Programme

Alexander von Humboldt-Stiftung

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.202013871

Reference46 articles.

2. Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

3. Ausgeprägte Methyleffekte in der Wirkstoff-Forschung und der Bedarf an neuen C-H-Methylierungsreaktionen

4. The Methylation Effect in Medicinal Chemistry

5. Challenging nature’s preference for methylation

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