Affiliation:
1. University of Texas at Austin Department of Chemistry 105 E 24th St. (A5300) Austin TX 78712-1167 USA
Abstract
AbstractThe first metal‐catalyzed oxidative alkynylations of primary alcohols or aldehydes to form α,β‐acetylenic ketones (ynones) are described. Deuterium labelling studies corroborate a novel reaction mechanism in which alkyne hydroruthenation forms a transient vinylruthenium complex that deprotonates the terminal alkyne to form the active alkynylruthenium nucleophile.
Funder
Welch Foundation
National Institute of General Medical Sciences