Affiliation:
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College 2A Nanwei Road, Xicheng District Beijing 100050 China
Abstract
AbstractNaphthospironone A, a polyhydroxy cagelike bioactive natural product, was synthesised for the first time in this study. The spiro[bicyclo[3.2.1]octane‐pyran] core was constructed by an acid‐promoted epoxide‐opening lactonisation and a base‐induced intramolecular aldol‐type cyclisation.
Funder
Chinese Academy of Medical Sciences Initiative for Innovative Medicine
Natural Science Foundation of Beijing Municipality