Affiliation:
1. Department of Chemistry University of North Carolina at Chapel Hill 27599-3290 Chapel Hill NC USA
Abstract
AbstractA practical method for the preparation of quaternary and tertiary allyl‐substituted heteroarenes by site‐selective couplings of heteroaryl nitriles and allylic nucleophiles is disclosed. Transformations utilize readily accessible stable reagents, proceed in the presence of a Lewis base activator, and undergo aryl‐C(sp3) quaternary and tertiary carbon formation with high γ‐selectivity (up to >98 : 2 γ : α).
Funder
National Institute of General Medical Sciences