An Activatable Near‐Infrared Fluorescent Probe for Precise Detection of the Pulmonary Metastatic Tumors: A Traditional Molecule Having a Stunning Turn

Author:

Jia Qian1,Zhang Ruili1,Yan Haohao1,Feng Yanbin1,Sun Fang1,Yang Zuo1,Qiao Chaoqiang1,Mou Xiaocheng1,Tian Jie1,Wang Zhongliang1ORCID

Affiliation:

1. Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular & Neuroimaging, Ministry of Education School of Life Science and Technology Xidian University Xi'an, Shaanxi 710126 China

Abstract

AbstractAn accurate detection of lung metastasis is of great significance for making better treatment choices and improving cancer prognosis, but remains a big challenge in clinical practice. In this study, we propose a reinventing strategy to develop a pH‐activatable near‐infrared (NIR) fluorescent nanoprobe, pulmonary metastasis tracer (denoted as PMT), based on assembly of NIR dye IR780 and calcium phosphate (CaP). By delicately tuning the intermolecular interactions during the assembly process and dye doping content, as well as the synthetic condition of probe, the fluorescence of PMT could be finely adjusted via the tumor acidity‐triggered disassembly. Notably, the selected PMT9 could sharply convert subtle pH variations into a distinct fluorescence signal to generate high fluorescence ON/OFF contrast, dramatically reducing the background signals. Benefiting from such preferable features, PMT9 is able to precisely identify not only the tumor sites in orthotopic lung cancer models but also the pulmonary metastases in mice with remarkable signal‐to‐background ratio (SBR). This study provides a unique strategy to turn shortcomings of traditional dye IR780 during in vivo imaging into advantages and further expand the application of fluorescent probe to image lung associated tumor lesions.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Postdoctoral Research Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

General Medicine

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