Catechol‐Isolated Atomically Dispersed Nanocatalysts for Self‐Motivated Cocatalytic Tumor Therapy

Author:

Wang Yuemei123,Qiu Shuwen3,Wang Liping12,Ji Penghao3,Guo Yuedong3,Yao Heliang1,Wei Chenyang1,Huo Minfeng3ORCID,Shi Jianlin123ORCID

Affiliation:

1. Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease Shanghai Institute of Ceramics Chinese Academy of Medical Sciences (2021RU012) Shanghai 200050 P. R. China

2. Centre of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China

3. Shanghai Tenth People's Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine The Institute for Biomedical Engineering & Nano Science School of Medicine Tongji University Shanghai 200072 P. R. China

Abstract

AbstractNanocatalytic tumor therapy based on Fenton nanocatalysts has attracted considerable attention because of its therapeutic specificity, enhanced outcomes, and high biocompatibility. Nevertheless, the rate‐determining step in Fenton chemistry, which involves the transition of a high‐valence metallic center (FeIII) to a Fenton‐active low‐valence metallic center (FeII), has hindered advances in nanocatalyst‐based therapeutics. In this study, we constructed mesoporous single iron atomic nanocatalysts (mSAFe NCs) by employing catechols from dopamine to coordinate and isolate single iron atoms. The catechols also serve as reductive ligands, generating a field‐effect‐based cocatalytic system that instantly reduces FeIII species to FeII species within the mSAFe NCs. This self‐motivated cocatalytic strategy enabled by mSAFe NCs accelerates the kinetics of the Fenton catalytic reaction, resulting in remarkable performance for nanocatalytic tumor therapy both in vitro and in vivo.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Shanghai Rising-Star Program

Fundamental Research Funds for the Central Universities

Key Research Program of Frontier Science, Chinese Academy of Sciences

Chinese Academy of Medical Sciences Initiative for Innovative Medicine

Publisher

Wiley

Subject

General Medicine

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