Total Synthesis of the Proposed Structure of Neaumycin B

Abstract

AbstractThe total synthesis of the proposed structure of anti‐glioblastoma natural product neaumycin B was achieved in 22 steps (longest linear sequence). The synthesis features HCl‐mediated [6,6]‐spiroketalization, a combination of Krische iridium‐catalyzed crotylation, Marshall palladium‐catalyzed propargylation, Fürstner nickel‐catalyzed regio‐ and enantioselective vicinal monoprotected diol formation, Brown crotylation and asymmetric halide‐aldehyde cycloaddition, so as to establish the challenging contiguous stereocenters.