Design of a Protein with Improved Thermal Stability by an Evolution‐Based Generative Model-Reference-Cited by-同舟云学术

Design of a Protein with Improved Thermal Stability by an Evolution‐Based Generative Model

Published:2022-11-16 Issue:50 Volume:134 Page:
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angewandte Chemie

Author:

Tian Pengfei¹²,Lemaire Adrien³,Sénéchal Fabien³,Habrylo Olivier³,Antonietti Viviane⁴,Sonnet Pascal⁴,Lefebvre Valérie³,Isa Marin Frederikke⁵,Best Robert B.¹,Pelloux Jérôme³,Mercadante Davide⁶^ORCID

Affiliation:

1. Laboratory of Chemical Physics National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Health Bethesda MD 20892-0520 USA

2. Current address: Flagship Labs 79, Inc. One Kendall Square. Cambridge MA 02139 USA

3. UMRT INRAE 1158 BioEcoAgro—BIOPI Biologie des Plantes et Innovation Université de Picardie 33 Rue St Leu 80039 Amiens France

4. UR 4294 AGIR Agents Infectieux Résistance chimiothérapie UFR de Pharmacie Université de Picardie 1, rue des Louvels 80037 Amiens France

5. Department of Computer Science University of Copenhagen Universitetsparken 1 2100 Copenhagen Denmark

6. School of Chemical Sciences The University of Auckland Private Bag 92019 1142 Auckland New Zealand

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.202202711

Reference68 articles.

1. Directed Evolution: Bringing New Chemistry to Life

2. Gerichtete Evolution: Wie man neue Chemie zum Leben erweckt

3. Highly accurate protein structure prediction with AlphaFold

4. How Many Protein Sequences Fold to a Given Structure? A Coevolutionary Analysis

5. The FoldX web server: an online force field

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