Affiliation:
1. 1102 Natural Sciences II Department of Chemistry University of California 92697-2025 Irvine CA USA
2. Department of Pharmaceutical Sciences 101 Theory University of California 92697 Irvine CA USA
Abstract
AbstractA radical/polar crossover annulation between allyl‐substituted arenes and electron‐deficient alkenes is described. Cobalt‐catalyzed hydrogen atom transfer (HAT) facilitates tandem radical C−C bond formation that generates functionalized tetralin products in the face of potentially problematic hydrofluorination, hydroalkoxylation, hydrogenation, alkene isomerization, and radical polymerization reactions. The reactions proceed under mild conditions that tolerate many functional groups, leading to a broad substrate scope. This powerful ring‐forming reaction very quickly assembles complex tetralins that are the formal products of the largely infeasible Diels–Alder cycloadditions of styrenes.
Funder
National Institute of General Medical Sciences