Affiliation:
1. Department of Chemical Sciences University of Padova Via Francesco Marzolo 1 35131 Padova Italy
2. Institut Lavoisier de Versailles University of Paris-Saclay 45 Avenue des Etats-Unis 78035 Versailles France
3. Université de Tours Faculté des Sciences et Techniques 37200 Tours France
Abstract
AbstractBicycloalkanes, cubanes and their structural analogues have emerged as bioisosteres of (hetero)arenes. To meet increasing demand, the chemical community has developed a plethora of novel synthetic methods. In this review, we assess the progress made in the field of light‐driven construction and functionalization of such relevant molecules. We have focused on diverse structural targets, as well as on reaction processes giving access to: (i) [1.1.1]‐bicyclopentanes (BCPs); (ii) [2.2.1]‐bicyclohexanes (BCHs); (iii) [3.1.1]‐bicycloheptanes (BCHeps); and (iv) cubanes; as well as other structurally related scaffolds. Finally, future perspectives dealing with the identification of novel reaction manifolds to access new functionalized bioisosteric units are discussed.
Funder
FP7 Ideas: European Research Council
Ministero dell’Istruzione, dell’Università e della Ricerca