A Diode‐Like Dye‐Cu Anisotropic Junction in a Coordination Polymer as a Logic State Ratchet for Intratumor Redox Photomodulation

Author:

Shi Yusheng1,Wang Peiyuan2,Li Mochen1,Zhang Tiexin1ORCID,Han Gang3ORCID,Duan Chunying1ORCID

Affiliation:

1. State Key Laboratory of Fine Chemicals School of Chemical Engineering Zhang Dayu School of Chemistry Dalian University of Technology 116024 Dalian P. R. China

2. Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of Matter Chinese Academy of Science 350002 Fuzhou P. R. China

3. Department of Biochemistry and Molecular Pharmacology University of Massachusetts Medical School 01605 Worcester MA USA

Abstract

AbstractRedox logic materials offer new avenues to modulate intracellular pathologic redox environment area‐specifically, but the unambiguity of redox logic states and their unidirectional and repetitive switchability are challenging to realize. By merging a bistable diisophthalic phenazine dye ligand with CuIIsalt, a multistable coordination polymer (CP) was constructed, of which the dye‐Cu anisotropic junction achieved the diode‐like unidirectional electron transfer and logic state ratchet for the first time. Radical cationic CP maintainedOFFstatus with low toxicity in healthy tissues, but was reduced to the neutralSERVOstate by the overexpressed glutathione (GSH) in hypoxic tumors. After photoirradiation, the stabilized charge‐separatedONstatus promoted photo‐Fenton reaction for reactive oxygen species (ROS) signal transduction, and simultaneously recovered the initial state for catalytic signal amplification of ROS, furnishing intratumor redox photomodulation for therapy.

Funder

National Natural Science Foundation of China

Postdoctoral Research Foundation of China

Publisher

Wiley

Subject

General Medicine

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