Comprehensive and High‐Throughput Exploration of Chemical Space Using Broadband 19 F NMR‐Based Screening-Reference-Cited by-同舟云学术

Comprehensive and High‐Throughput Exploration of Chemical Space Using Broadband 19 F NMR‐Based Screening

Published:2020-06-22 Issue:35 Volume:132 Page:14919-14927
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Lingel Andreas¹²^ORCID,Vulpetti Anna²^ORCID,Reinsperger Tony³,Proudfoot Andrew¹,Denay Regis²,Frommlet Alexandra¹^ORCID,Henry Christelle⁴,Hommel Ulrich⁴,Gossert Alvar D.⁴,Luy Burkhard³^ORCID,Frank Andreas O.¹^ORCID

Affiliation:

1. Global Discovery Chemistry Novartis Institutes for BioMedical Research 5300 Chiron Way Emeryville CA 94608 USA

2. Global Discovery Chemistry Novartis Institutes for BioMedical Research Novartis Campus 4056 Basel Switzerland

3. Institute of Organic Chemistry and Institute for Biological Interfaces 4 – Magnetic Resonance Karlsruhe Institute of Technology (KIT) 76131 Karlsruhe Germany

4. Chemical Biology and Therapeutics Novartis Institutes for BioMedical Research Novartis Campus 4056 Basel Switzerland

Funder

Deutsche Forschungsgemeinschaft

Helmholtz-Gemeinschaft

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.202002463

Reference37 articles.

1. Twenty years on: the impact of fragments on drug discovery

2. Promiscuity: what protects us, perplexes us

3. Current perspectives in fragment-based lead discovery (FBLD)

4. Discovering High-Affinity Ligands for Proteins: SAR by NMR

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1. Efficient Screening of Target‐Specific Selected Compounds in Mixtures by ¹⁹ F NMR Binding Assay with Predicted ¹⁹ F NMR Chemical Shifts;ChemMedChem;2022-05-12

2. Hydrogen Bond Acceptor Propensity of Different Fluorine Atom Types: An Analysis of Experimentally and Computationally Derived Parameters;Chemistry – A European Journal;2021-05-27

3. 19F NMR viewed through two different lenses: ligand-observed and protein-observed 19F NMR applications for fragment-based drug discovery;RSC Chemical Biology;2021