Affiliation:
1. School of Chemistry & Chemical Engineering Yangzhou University Yangzhou 225002 China
2. Department of Chemistry Fudan University 2005 Songhu Road Shanghai 200438 China
Abstract
AbstractThe palladium‐catalyzed asymmetric carboamination reaction is one of the most significant transformations in organic chemistry. Herein, we report the first palladium‐catalyzed asymmetric alleneamination of β,γ‐unsaturated hydrazones with propargylic acetates. This protocol enables the efficient installation of various multisubstituted allene groups onto dihydropyrazoles in good yields with excellent enantioselectivities. The chiral sulfinamide phosphine ligand Xu‐5 exhibits highly efficient stereoselective control in this protocol. The salient features of this reaction include the readily available starting materials, a broad substrate scope, an easy scale‐up, mild reaction conditions and versatile transformations.
Funder
National Natural Science Foundation of China
Cited by
2 articles.
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