Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation-Reference-Cited by-同舟云学术

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Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation

Published:2021-03-26 Issue:19 Volume:133 Page:11014-11022
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Biggs George S.¹^ORCID,Klein Oskar James¹²^ORCID,Maslen Sarah L.³^ORCID,Skehel J. Mark³^ORCID,Rutherford Trevor J.³^ORCID,Freund Stefan M. V.³^ORCID,Hollfelder Florian²^ORCID,Boss Sally R.¹^ORCID,Barker Paul D.¹^ORCID

Affiliation:

1. Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW UK

2. Department of Biochemistry University of Cambridge Tennis Court Road Cambridge CB2 1GA UK

3. MRC Laboratory of Molecular Biology Francis Crick Avenue, Cambridge Biomedical Campus Cambridge CB2 0QH UK

Funder

Engineering and Physical Sciences Research Council

European Research Council

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.202015834

Reference81 articles.

1. Artificial Metalloenzymes on the Verge of New-to-Nature Metabolism

2. Engineered Metalloenzymes with Non‐Canonical Coordination Environments

3. Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions

4. Genetische Optimierung von Metalloenzymen: Weiterentwicklung von Enzymen für nichtnatürliche Reaktionen

5. Artificial Metalloenzymes

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