A Nanomedicine‐Enabled Ion‐Exchange Strategy for Enhancing Curcumin‐Based Rheumatoid Arthritis Therapy

Author:

Yang Jiacai12,Yang Bowen1ORCID,Shi Jianlin13ORCID

Affiliation:

1. Shanghai Institute of Ceramics Chinese Academy of Sciences Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease Chinese Academy of Medical Sciences (2021RU012) Shanghai 200050 P. R. China

2. Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China

3. Tenth People's Hospital and School of Medicine Tongji University Shanghai 200092 P. R. China

Abstract

AbstractCurcumin (Cur) has been clinically used for rheumatoid arthritis treatment by the means of reactive oxygen species (ROS) scavenging and immune microenvironment regulation. However, this compound has a poor water solubility and moderate antioxidative activity, favoring no further broadened application. Metal complexes of curcumin such as zinc‐curcumin (Zn−Cur) features enhanced water solubilities, while copper‐curcumin (Cu−Cur) shows a higher antioxidant activity but lower solubility than Zn−Cur. Based on their inherent biological properties, this work proposes a nanomedicine‐based ion‐exchange strategy to enhance the efficacy of Cur for rheumatoid arthritis treatment. Copper silicate nanoparticles with hollow mesoporous structure were prepared to load water‐soluble Zn−Cur for constructing a composite nanomedicine, which can degrade in acidic microenvironment of arthritic region, releasing Cu2+ and Zn−Cur. Cu2+ then substitute for Zn2+ in Zn−Cur to form Cu−Cur with a significantly enhanced antioxidative effect, capable of efficiently scavenging ROS in M1 macrophages, promoting their transition to an anti‐inflammatory M2 phenotype. In addition, the silicate released after nanocarrier degradation and the Zn2+ released after ion exchange reaction synergistically promote the biomineralization of osteoblasts. This work provides a new approach for enhancing the antiarthritic effect of Cur via an ion‐exchange strategy.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Shanghai Rising-Star Program

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

General Medicine

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