Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine**-Reference-Cited by-同舟云学术

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine**

Published:2021-04-06 Issue:20 Volume:133 Page:11575-11581
ISSN:0044-8249
Container-title:Angewandte Chemie
language:en
Short-container-title:Angew. Chem.

Author:

Li Zhangqiang¹,Jin Xueqin¹,Wu Tong¹,Huang Gaoxingyu²,Wu Kun³,Lei Jianlin⁴,Pan Xiaojing¹,Yan Nieng⁵^ORCID

Affiliation:

1. State Key Laboratory of Membrane Biology Beijing Advanced Innovation Center for Structural Biology Tsinghua-Peking Joint Center for Life Science School of Life Sciences Tsinghua University Beijing 100084 China

2. Key Laboratory of Structural Biology of Zhejiang Province Institute of Biology, Westlake Institute for Advanced Study School of Life Sciences Westlake University Hangzhou 310024 Zhejiang Province China

3. Medical Research Center Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China

4. Technology Center for Protein Sciences Ministry of Education Key Laboratory of Protein Sciences School of Life Sciences Tsinghua University Beijing 100084 China

5. Department of Molecular Biology Princeton University Princeton NJ 08544 USA

Publisher

Wiley

Subject

General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.202102196

Reference66 articles.

2. Ion Channel Macromolecular Complexes in Cardiomyocytes: Roles in Sudden Cardiac Death

3. Identification of two sodium channel subtypes in chick heart and brain.

4. Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

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